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BiCNU Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when BiCNU is combined with any of the drugs listed above.
Amphotericin B
Combining amphotericin B with chemotherapy medicines, such as BiCNU, may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and breathing problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
Certain Immunosuppressant Medicines
Using BiCNU in combination with other medicines that suppress the immune system could increase your risk for potentially serious side effects, including low blood cell counts and infections. It is generally recommended that BiCNU not be used in combination with some of these medicines, while other combinations can be used together with careful monitoring. Talk to your healthcare provider about this potential interaction if you are taking other immunosuppressant medicines.
People who take cimetidine during BiCNU treatment may have a greater risk for bone marrow suppression and low blood cell counts. Talk to your healthcare provider before using these medicines together. If you are taking cimetidine, talk to your healthcare provider. He or she can recommend cimetidine alternatives that are not likely to react with BiCNU.
Taking clozapine with BiCNU could put you at risk for dangerously low white blood cell counts, which could make you susceptible to potentially serious infections. Talk to your healthcare provider before using these medicines together. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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