Colorectal cancer is a disease in which cancerous cells originate in the tissue of the colon or rectum. Cancer that begins in the colon is called colon cancer, and cancer that begins in the rectum is called rectal cancer; colorectal cancer is another name for these forms of cancer.
Bevacizumab is given along with chemotherapy in order to help chemotherapy work better. It is approved for use with chemotherapy regimens that contain 5-fluorouracil (5-FU, Adrucil®) to treat colon or rectal cancer that has spread to other parts of the body (known as metastatic cancer). It is approved for first-line or second-line treatment, which means it can be part of the first regimen that is tried, or it can be used after another regimen has failed.
Bevacizumab also gained recent FDA approval for second-line treatment of metastatic colorectal cancer after failure with a first-line treatment containing bevacizumab. Approved second-line treatment contains bevacizumab in combination with fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin regimens.
Why Is Bevacizumab Used for Brain Cancer?
Bevacizumab is approved for treating glioblastoma (a type of brain cancer) in individuals with progression (worsening) of cancer after other treatments. It is approved to be used by itself for this particular use.
Why Is Bevacizumab Used for Kidney Cancer?
Bevacizumab is approved for renal cell carcinoma. In particular, it is approved for treating renal cell carcinoma that has spread to other areas of the body (metastatic cancer) and only in combination with another medication known as interferon alpha.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Avastin [package insert]. San Francisco (CA): Genentech, Inc.;2013 January.
Food and Drug Administration, Center for Drug Evaluation and Research. FDA begins process to remove breast cancer indication from Avastin label (12/16/2010). FDA Web site. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2010/ucm237172.htm. Accessed March 15, 2011.
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