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Guidelines for dosing bendamustine will depend on your height and weight. Other factors that may affect your amount include the reason you are using this drug and other medications you are taking. Bendamustine is given as an intravenous injection for two days in a row, every 21 to 28 days. It is administered in a healthcare setting and takes about 30 to 60 minutes for each dose.

An Introduction to Your Dosage of Bendamustine

The dose of bendamustine (Treanda®) your healthcare provider recommends will vary, based on a number of factors, including:
  • Your height and weight
  • The reason you are using it
  • How you respond to the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Bendamustine Dose for Chronic Lymphocytic Leukemia

The recommended bendamustine dose for the treatment of chronic lymphocytic leukemia (CLL) is based on body surface area, which is normally calculated using height and weight. Dosing based on body surface area is expressed as milligrams per meters squared (mg per m2).
Specifically, the recommended dose is 100 mg per m2 given intravenously (by IV) over 30 minutes. This dose is given once a day for two days in a row every 28 days. This 28-day period is called a treatment cycle. Bendamustine is given on days one and two of the cycle, followed by 26 days without treatment. The cycle may then be repeated up to six times.
Your healthcare provider may reduce your amount or recommend a longer break between doses if you experience potentially serious bendamustine side effects, such as low blood cell counts. For example, some people with CLL may be given doses as low as 25 mg per m2.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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