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Anzemet is a prescription drug used for preventing nausea and vomiting due to surgery and chemotherapy. It works by blocking serotonin, a chemical in the body that is associated with nausea and vomiting. The medication comes in tablet form and is usually taken one hour before chemotherapy. When used before surgery, an IV form is given. Potential side effects of the drug include dizziness, fatigue, diarrhea, and headaches.

What Is Anzemet?

Anzemet® (dolasetron mesylate) is a prescription nausea and vomiting medication. It is approved for nausea and vomiting due to the following causes:
 
  • Surgery (both prevention and treatment, for the intravenous form only)
  • Chemotherapy (prevention, for the tablet form only).
 
(Click Anzemet Uses for more information on what the medication is used for, including possible off-label uses.)
 

Who Makes It?

Anzemet is made by sanofi-aventis.
 

How Does It Work?

Nausea (upset stomach) and vomiting are complex processes involving many chemicals in the body and several parts of the body, including the brain and small intestine. It is likely that Anzemet works in the small intestine, but it may also work in the brain.
 
The medication works by blocking serotonin, a chemical produced by the body that is associated with nausea and vomiting. Serotonin has many effects in the body and has several receptors where it can bind. Anzemet blocks serotonin at a specific type of receptor (the 5-HT3 receptor), which is important for nausea and vomiting. It has no effects on other types of serotonin receptors in the body.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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