Cancer Home > Drug Interactions With Altretamine
The following sections explain in detail the potentially negative reactions that can occur when altretamine is combined with any of the drugs listed above.
Using amphotericin B in combination with chemotherapy medicines, including altretamine, may increase the risk for potentially serious amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you take these medicines together.
Biologic and Immunologic Medications
If you take certain biologic and immunologic medicines in combination with altretamine, it may increase your risk for potentially serious side effects, such as infections and anemia. Altretamine should not be used in combination with some biologic or immunologic medicines, while other combinations will require close monitoring. Talk to your healthcare provider about this potential interaction if you are taking a biologic or immunologic medicine.
Cimetidine may increase blood levels of altretamine, potentially increasing the risk for altretamine side effects. Talk to your healthcare provider before taking cimetidine during altretamine therapy. There are similar medicines your healthcare provider may be able to recommend that are less likely to react with altretamine.
Taking clozapine and altretamine together may cause extremely low white blood cell counts, which would increase your risk for life-threatening infections. Talk to your healthcare provider about this potential interaction if you take clozapine. You should not stop taking clozapine unless your healthcare provider specifically tells you to do so.
Echinacea could potentially decrease the effectiveness of altretamine. Do not take echinacea during altretamine treatment without first speaking with your healthcare provider.
Live vaccines contain live viruses or bacteria. It is generally recommended that people receiving chemotherapy not receive live vaccines. This is because chemotherapy medicines, including altretamine, may increase your risk for infections, and you could become infected with the virus or bacteria used to make a live vaccine. Also, live vaccines may be less effective during chemotherapy treatment. Talk to your healthcare provider before getting a vaccination while you are taking this drug.
Monoamine Oxidase Inhibitors (MAOIs)
Combining an MAOI with altretamine may increase your risk for extremely low blood pressure, especially when getting up from a seated or lying position. This could cause you to become faint or fall down. If you take these medicines together, make sure you sit up or stand slowly, especially if you feel dizzy or faint.
In a clinical study, pyridoxine was shown to reduce the nervous system side effects associated with altretamine. However, pyridoxine also reduced the effectiveness of altretamine and, therefore, should probably not be used in combination with altretamine.
Combining roflumilast with altretamine may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before taking these medicines together.
Sipuleucel-T is thought to work by stimulating the body's immune system. Because altretamine decreases the activity of the immune system, it could decrease the effectiveness of sipuleucel-T. Talk to your healthcare provider about this possible interaction before taking these medicines together.
Tricyclic Antidepressants (TCAs)
Combining a TCA with altretamine may increase your risk for extremely low blood pressure, especially when getting up from a seated or lying position. This could cause you to become faint or fall down. If you take these medicines together, make sure you sit up or stand slowly, especially if you feel dizzy or faint.