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Aloxi uses are focused on the prevention of nausea and vomiting caused by chemotherapy or surgery. When used before chemotherapy, the IV form of the medication is "long-acting," meaning it can help prevent nausea and vomiting for up to several days after chemotherapy. Healthcare providers may also recommend off-label Aloxi uses, such as for preventing nausea or vomiting due to other causes. The drug is currently not approved for use in children.

Uses of Aloxi: An Overview

Aloxi® (palonosetron hydrochloride) is a prescription medication approved for the prevention of nausea and vomiting due to surgery or chemotherapy. The IV (intravenous) form is a long-acting medication that can prevent nausea and vomiting for several days after chemotherapy with just a single dose.
Although Aloxi was initially available only in injectable form, it is now available in capsule form as well. Aloxi capsules are approved only for preventing acute nausea and vomiting due to chemotherapy; they are not approved for use before surgery.

Using Aloxi for Nausea and Vomiting Due to Chemotherapy

Nausea and vomiting are some of the more common and debilitating side effects of chemotherapy (see Chemotherapy Side Effects). Some types of chemotherapy are more likely to cause this than others. In addition, nausea and vomiting from chemotherapy are likely due to many causes.
The main symptoms of nausea are feeling sick to your stomach and feeling like you might vomit (as opposed to vomiting, which is actually "throwing up"). In general, Aloxi (as well as most nausea and vomiting medications) is better at preventing vomiting than preventing nausea. It is much easier to prevent nausea and vomiting than to treat it once it starts.
Aloxi is licensed to prevent nausea and vomiting, but it is not a treatment for it.
Aloxi injection is unique in that it is approved to prevent nausea and vomiting both in the "acute phase" (the first 24 hours after chemotherapy) and the "delayed phase" (24 hours after) with just a single dose. It is given by IV about 30 minutes before the start of chemotherapy.
It is not clear if the capsule form of Aloxi lasts equally as long (currently, it is approved only to prevent acute phase nausea). The capsule form is taken about one hour before the start of chemotherapy.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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