Cancer Home > Aldesleukin Dosage

Aldesleukin is given as an intravenous (IV) infusion by a healthcare provider in a healthcare setting, such as a hospital. The infusion is given every eight hours for five days, followed by nine days without treatment, and then another five days of treatment. The specific dosage of aldesleukin your healthcare provider administers will depend on your weight and how well you tolerate the drug.

An Introduction to Your Dosage of Aldesleukin

The dose of aldesleukin (Proleukin®) your healthcare provider recommends may vary, depending on how you tolerate the medication. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Aldesleukin Dosing Guidelines

The standard recommended dose of aldesleukin for the treatment of renal cell carcinoma (kidney cancer) and melanoma (skin cancer) is 0.37 mg per kg body weight (about 0.17 mg per lb) every eight hours for five days, or a maximum of 14 doses. After nine days without treatment, the dosing schedule will repeat for another five days for a maximum of 14 additional doses.
This five days of treatment, nine days of rest, and five additional days of treatment constitutes one treatment course.
Your healthcare provider may recommend you skip a dose if you are experiencing potentially serious or intolerable aldesleukin side effects. In clinical trials, doses were often withheld due to side effects, and many people were unable to tolerate an entire 28-dose course of treatment.
Your healthcare provider may recommend additional courses of treatment if your tumors have reduced in size and you did not experience dangerous side effects. Each treatment course should be separated by at least seven weeks.

General Information on Receiving Aldesleukin

Some considerations to keep in mind during treatment with aldesleukin include the following:
  • This medication is given as a slow injection into a vein (an intravenous, or IV, infusion) every eight hours for five days, followed by a nine-day break, and then an additional five days of treatment.
  • The injection is normally administered by a healthcare provider in a healthcare setting, such as a hospital.
  • It takes 15 minutes to complete each aldesleukin IV infusion.
  • Your healthcare provider may give you other medicines to help prevent or manage certain aldesleukin side effects.
  • Aldesleukin should be inspected before use, and should not be given if it contains particles or is discolored.
  • For the medication to work properly, it must be used as prescribed.
  • If you are unsure about anything related to your dosage or aldesleukin dosing in general, please talk to your healthcare provider or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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