Cancer Home > Actiq Drug Interactions

Several medications can cause potentially dangerous drug interactions with Actiq, including amphetamines, sleep medications, and antipsychotics. These interactions could increase your risk for serious side effects, such as extreme drowsiness, confusion, and difficulty breathing. To avoid any complications, make sure your healthcare provider is aware of any other medications you are taking, including nonprescription drugs and herbal supplements.

An Overview of Interactions With Actiq

Actiq® (fentanyl lozenge) is a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. This product may potentially interact with many other medications.
 
Some of the medications that may lead to Actiq drug interactions include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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