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CYP 3A4 Inhibitor Medications
The body breaks down Actiq using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining Actiq with one of these CYP 3A4 inhibitors may increase the level of Actiq in your body, increasing your risk for serious side effects, including drowsiness, confusion, and difficulty breathing. Your healthcare provider may monitor you more closely for side effects if you use Actiq with a CYP 3A4 inhibitor.
Actiq can increase the risk of desmopressin side effects. Talk to your healthcare provider prior to using these medications together.
Grapefruit juice may increase the amount of Actiq in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using Actiq.
Medications That Cause Drowsiness
Actiq causes significant drowsiness. Taking other medications that cause drowsiness while using Actiq may lead to serious side effects, such as extreme sedation, confusion, and serious breathing problems. Check with your healthcare provider before using Actiq with other medications that can cause drowsiness.
Monoamine Oxidase Inhibitors (MAOIs)
Combining Actiq with an MAOI may potentially cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use Actiq if you have taken an MAOI within the past 14 days.
Combining octreotide with Actiq may increase the pain-relieving effects of Actiq. Your healthcare provider may monitor your pain response if you use these medications together. You might need a lower Actiq dosage.