Cancer Home > Abstral Drug Interactions

There are a number of drugs that may cause negative interactions with Abstral. Problems may occur if the narcotic is taken with products such as amphetamines, antidepressants, grapefruit juice, or alcohol. Some interactions could increase your risk for side effects (such as drowsiness, confusion, memory loss, or difficulty breathing), while others can lead to more dangerous problems.

An Overview of Interactions With Abstral

Abstral® (fentanyl sublingual tablets) is a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. This product may potentially react with many other medications.
 
Some of the drugs that may lead to Abstral interactions include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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