Cancer Home > Drug Interactions With Abiraterone

Silodosin
Taking abiraterone with silodosin may increase blood levels of silodosin, possibly increasing the risk for side effects. In general, it is not recommended to take silodosin with abiraterone.
 
Tamoxifen
Combining abiraterone with tamoxifen can make tamoxifen less effective. These medications should not be taken together.
 
Tetrabenazine
Abiraterone can increase blood levels of tetrabenazine, which could increase the risk for tetrabenazine side effects. Your healthcare provider may choose to give you a lower tetrabenazine dose if you take it with abiraterone.
 
Thioridazine
Abiraterone may increase the level of thioridazine in the bloodstream, increasing the risk for potentially serious side effects, including heart rhythm problems. These medications should not be taken together.
 
Topotecan
Abiraterone can increase the level of topotecan in the bloodstream, possibly increasing the risk for side effects. In general, abiraterone should not be used with oral topotecan, and should be used with caution in combination with intravenous (IV) topotecan.
 
Tramadol
Abiraterone may decrease the effectiveness of tramadol. If you take these medicines together, let your healthcare provider know if tramadol is not controlling your pain. You may need a different pain medication.
 

Final Thoughts

Abiraterone has the potential to interact with numerous medications, far too many to include in this article. Therefore, you should talk with your pharmacist or healthcare provider about specific drug interactions that may apply to you.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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