Letrozole Dosing

Letrozole dosing guidelines typically call for a starting dose of 2.5 mg once daily when treating breast cancer in postmenopausal women. Those who have severe liver disease may be prescribed a lower dose. Among the factors that can affect the letrozole dosage your healthcare provider recommends are the stage of the breast cancer, other medical conditions you may have, and other medications you may be taking.

An Introduction to Letrozole Dosing

The dose of letrozole (Femara®) that your healthcare provider recommends will vary depending on a number of factors, including:
 
As always, do not adjust your letrozole dosage unless your healthcare provider specifically instructs you to do so.
 

Letrozole Dosing for Breast Cancer

The recommended dose of letrozole in postmenopausal women is 2.5 mg, taken once daily.
 
People with liver disease, including liver failure or cirrhosis, may need to take a lower letrozole dose.
 

General Information on Letrozole Dosing

Following are some considerations for people taking letrozole:
 
  • The medication comes in tablet form and is taken by mouth once a day.
     
  • You can take it with or without food. If the medication bothers your stomach, try taking it with food.
     
  • Letrozole should be taken at the same time each day to maintain even levels of the medicine in your blood.
     
  • For the medication to work properly, it must be taken as prescribed. Letrozole will not work if you stop taking it.
     
  • If you are unsure about anything related to your dosage or letrozole dosing in general, talk with your healthcare provider, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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