Drug Interactions With Letrozole

When you take certain other medicines along with letrozole, they may reduce the effectiveness of the letrozole in your system. Among the drugs that can potentially interact with letrozole are oral contraceptives (birth control pills) and estrogens or other hormone replacement therapy. You should be sure to talk with your pharmacist or healthcare provider about any drug interactions with letrozole that may apply to you.

 

An Introduction to Drug Interactions With Letrozole

Letrozole (Femara®) can potentially interact with other medications. Some of these medicines that may lead to drug interactions with letrozole include:
 

More Information on Interactions With Letrozole

The following sections explain in detail the potentially negative interactions that can occur when letrozole is combined with any of the drugs listed above.
 
Estrogens
Estrogens may decrease the effectiveness of letrozole. Therefore, these two medications should not be combined.
 
Oral Contraceptives
Oral contraceptives may also decrease the effectiveness of letrozole and should not be taken with it. Talk to your healthcare provider about alternative birth control methods.
 

Final Thoughts on Drug Interactions With Letrozole

It is possible that not all letrozole drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with letrozole that may apply to you.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;