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Lapatinib Dosing

For those who are being treated for breast cancer with lapatinib, dosing typically starts at 1250 mg or 1500 mg a day. Lower amounts may be necessary in some situations, such as if you have severe liver disease. This medication should be taken at least an hour before or after a meal.

Lapatinib Dosing: An Introduction

The dose of lapatinib (Tykerb®) that your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • Other medications you may be taking
  • Other medical conditions you may have.
     
As is always the case, do not adjust your lapatinib dose unless your healthcare provider specifically instructs you to do so.
 

Lapatinib Dosing in Combination With Xeloda

The usual recommended dose of lapatinib in combination with Xeloda® (capecitabine) for treating breast cancer is 1250 mg (five tablets), taken once daily, at least one hour before or one hour after a meal. Lapatinib is taken every day for a 21-day cycle, and capecitabine is taken only on days 1 through 14 of that cycle. After 21 days, the cycle is started over, with no days in between. Essentially, lapatinib is taken every single day, but capecitabine is taken for two-week periods with one week in between.
 
Lapatinib (along with capecitabine) is usually taken until the cancer becomes worse or until dangerous or bothersome side effects of lapatinib occur.
 

Lapatinib Dosage in Combination with Femara

The usual recommended dose of lapatinib in combination with Femara® (letrozole) for breast cancer treatment is 1500 mg (six tablets, all at once), taken once daily at least one hour before or one hour after a meal. The usual dosage of Femara when used in combination with lapatinib is 2.5 mg once daily. These two medications are used continuously, not in cycles.
 
The Zen of Cancer Caregiving - Recharge Your Batteries!

Lapatinib for Breast Cancer

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