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Kyprolis Side Effects

It is difficult to predict whether you will experience side effects with Kyprolis. However, as with other chemotherapy drugs, side effects are common with Kyprolis, and most people who use this drug will develop some type of reaction. Some of the most common problems include fatigue, nausea, and diarrhea. More serious reactions, such as infections and bleeding, may require medical treatment.


An Introduction to Kyprolis Side Effects

As with any chemotherapy medicine, Kyprolis™ (carfilzomib) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with Kyprolis. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Kyprolis

Kyprolis has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people receiving the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In clinical studies, the most common Kyprolis side effects included:
  • Fatigue -- in up to 55.5 percent of people
  • Anemia (low red blood cell counts) -- up to 46.8 percent (see Chemotherapy and Anemia)
  • Nausea -- up to 44.9 percent
  • Low platelet counts (which could increase the risk for bleeding) -- up to 36.3 percent (see Blood Clotting Problems and Chemotherapy)
  • Shortness of breath -- up to 34.6 percent
  • Diarrhea -- up to 32.7 percent
  • Fever -- up to 30.4 percent
  • Upper respiratory tract infection (such as the common cold) -- up to 28.3 percent
  • Headache -- up to 27.6 percent
  • Cough -- up to 26 percent.
Other common reactions, occurring in 10.3 percent to 24.1 percent of people, included:
  • An increase in blood creatinine levels, which could be a sign of kidney problems
  • Swelling of the arms, hands, legs, ankles, or feet
  • Vomiting
  • Constipation
  • A low level of white blood cells in the blood, which could increase the risk for infection (see Chemotherapy and Infections)
  • Back pain
  • Insomnia
  • Chills
  • Joint pain
  • High blood pressure (hypertension)
  • Loss of strength and energy
  • Low levels of potassium in the blood (hypokalemia)
  • Low levels of magnesium in the blood (hypomagnesemia)
  • Arm and leg pain
  • Pneumonia
  • Increase in certain liver enzymes, which could be a sign of liver problems
  • Dizziness
  • Reduced sense of touch
  • Loss of appetite
  • General pain
  • High blood sugar levels (hyperglycemia)
  • Chest pain
  • High blood calcium levels (hypercalcemia)
  • Low blood phosphate levels (hypophosphatemia)
  • Low blood sodium levels (hyponatremia).
The Zen of Cancer Caregiving - Recharge Your Batteries!

Kyprolis Chemotherapy Information

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