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Kyprolis Drug Interactions

Aripiprazole, clozapine, and pimozide are drugs that may interact with Kyprolis. Some reactions due to these combinations may include side effects and serious infections. To help ensure a safe treatment and minimize potentially serious complications, tell your healthcare provider about all other medicines, vitamins, and supplements you are taking before starting treatment with Kyprolis.

An Overview of Interactions With Kyprolis

Kyprolis™ (carfilzomib) can potentially react with a few other medications. Some of the products that may lead to drug interactions with Kyprolis include but are not limited to:

Kyprolis Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Kyprolis is combined with any of the drugs listed above.
Kyprolis may increase blood levels of aripiprazole, which could increase your risk for aripiprazole side effects. If you use these medicines together, let your healthcare provider know if you may be experiencing more side effects from aripiprazole. He or she may choose to adjust your aripiprazole dosage.  
Taking clozapine with Kyprolis may increase the risk for dangerously low white blood cells, which would increase your risk for potentially serious infections. Talk to your healthcare provider before using these medicines together. Do not stop taking clozapine, however, unless your healthcare provider specifically tells you to do so.
Kyprolis may increase blood levels of pimozide, which could increase the risk for potentially serious pimozide side effects. Talk to your healthcare provider about this potential interaction before using these drugs together.  
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