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Kyprolis and Pregnancy

As a pregnancy Category D medication, Kyprolis (carfilzomib) may not be safe for pregnant women. Although adequate research has not been done in pregnant women, Kyprolis has been shown to increase the risk of miscarriage when given to pregnant animals. However, there may be situations when the benefits of using the drug outweigh the possible risks to the unborn child.


Can Pregnant Women Use Kyprolis?

Kyprolis™ (carfilzomib) is a prescription injection medication approved for the treatment of multiple myeloma. This product may cause fetal harm if given to a pregnant woman.

What Is Pregnancy Category D?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category D is a classification given to medicines that have been shown to present a risk to the fetus in studies of pregnant women but may still offer benefits that outweigh the risks the drug presents. A pregnancy Category D medicine can still be given to a pregnant woman if her healthcare provider believes that the benefits to the woman outweigh the possible risks to the unborn child.
Kyprolis did not cause birth defects when given to pregnant rats and rabbits in animal studies. However, it increased the risk for miscarriage in the pregnant rabbits at doses that were less than the equivalent recommended human dose. The medication has not been adequately studied in pregnant women.
Kyprolis is generally not recommended for use in pregnant women. However, there may be times when a healthcare provider recommends its use despite the risks, such as in cases where safer treatments are not an option.
Women of childbearing potential should use effective birth control to prevent pregnancy during Kyprolis treatment. Talk to your healthcare provider about the best birth control options for your particular situation.
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