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Dosing Information for Irinotecan

The dose of irinotecan your healthcare provider recommends will vary, depending on:
  • Your height and weight
  • How you tolerate the medication
  • Other medications you are taking (whether you are using irinotecan alone or in combination with other chemotherapy medicines)
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Irinotecan Dosage for more information.)

Drug Interactions

Irinotecan may potentially interact with a number of other medicines (see Drug Interactions With Irinotecan).

What If I Overdose on This Medicine?

An overdose with this medication can be quite dangerous and could even cause death. Seek immediate medical attention if you believe you have been given too much irinotecan.
(Click Camptosar Overdose for more information.)

What Should I Do If I Miss a Dose of Irinotecan?

If you miss a dose of irinotecan, contact your healthcare provider right away to reschedule your appointment. It is important to keep your scheduled appointments during irinotecan treatment.

How Does It Work?

Irinotecan belongs to a group of medicines known as topoisomerase I inhibitors. Topoisomerase I is an enzyme that helps relax DNA that has been overwound, which can occur when DNA is duplicating so cells can divide. It does this by breaking the DNA strand to relieve the strain and then putting the strand back together. Irinotecan binds to topoisomerase I and prevents the enzyme from repairing the broken DNA, and this causes the cell to die.
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Irinotecan Drug Information

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