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Drug Interactions With Ipilimumab

Digoxin, warfarin, and certain other drugs may cause negative interactions when combined with ipilimumab. Some of these reactions can increase the risk for potentially serious complications, such as low blood pressure, kidney damage, and problems breathing. Your healthcare provider may need to monitor you more closely if you are undergoing ipilimumab treatment and take medications such as these.

An Overview of Ipilimumab Interactions

Ipilimumab (Yervoy™) may react with several other medications. Some of the drugs that may interact with ipilimumab include but are not limited to:
 
 

More Detail on Drug Interactions With Ipilimumab

The following sections explain in detail the potentially negative interactions that can occur when ipilimumab is combined with any of the drugs listed above.
 
Amphotericin B
Combining ipilimumab with amphotericin B could increase your risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and breathing difficulties due to constriction of the muscles around the airways (bronchospasm). Your healthcare provider may monitor you more closely for these problems if you use these drugs together.
 
Digoxin
Ipilimumab may decrease the amount of digoxin absorbed into the bloodstream, which could make digoxin less effective. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
 
Vemurafenib  
In studies, some people taking both ipilimumab and vemurafenib developed increased liver enzymes and sometimes increased bilirubin, which might be a sign of liver damage. Check with your doctor before combining these medications.
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Ipilimumab Drug Information

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