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Drug Interactions With Imatinib

Lurasidone
Imatinib can increase blood levels of lurasidone, which could increase your risk for side effects. It is generally recommended that these medicines not be taken together.
 
Natalizumab
Combining imatinib with natalizumab may increase your risk for developing infections, including potentially serious infections. It is generally recommended that these medications not be taken together.
 
P-Glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, out of body tissues so they can be excreted through the urine or feces. Pgp helps remove imatinib from the body, and medications known as Pgp inducers increase the activity of Pgp.
 
Taking imatinib with one of these drugs causes imatinib to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove imatinib from the body, and medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking imatinib with one of these drugs causes imatinib to be removed from the body more slowly, potentially increasing imatinib blood levels and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
Pimecrolimus
In general, people taking imatinib should not use pimecrolimus because of an increased risk for infection, lymphoma (cancer of the lymph nodes), and skin cancer. Talk to your healthcare provider before taking these medicines together.
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