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Drug Interactions With Imatinib

CYP 3A4 Inducer Medications
The body breaks down imatinib using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining imatinib with one of these drugs may decrease the level of imatinib in your body, potentially making it less effective.
 
It is generally recommended that imatinib not be combined with CYP 3A4 inducers. However, if such a combination cannot be avoided, your healthcare provider will likely give you a higher imatinib dose.
 
CYP 3A4 Inhibitor Medications
The body breaks down imatinib using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining imatinib with one of these drugs may increase the level of imatinib in your body, potentially increasing your risk for side effects. If you take these medications together, your healthcare provider may need to monitor you more closely.
 
Denosumab
Taking denosumab with imatinib could increase your risk for potentially serious infections. Talk to your healthcare provider before taking these medicines together. Also, contact your healthcare provider if you develop any symptoms of an infection, such as:
 
  • Fever
  • Chills
  • Aches and pains
  • Coughing.
     
Echinacea
Imatinib may be less effective if it is taken with echinacea. Do not take these medications together unless your healthcare provider tells you otherwise.
 
Eplerenone
Combining eplerenone with imatinib may increase the amount of eplerenone in your body, increasing your risk for potentially serious side effects. In general, these medications should not be taken together.
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