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What Is Ifosfamide Used For?

Ifosfamide is a type of alkylating agent prescribed to treat testicular cancer after at least two other forms of treatment have failed. It is approved for use in adults only. Possible off-label uses can include treating other types of cancer, such as leukemia, lymphoma, or pancreatic cancer. This chemotherapy drug works by disrupting how cancer cells grow and multiply.

An Overview of Uses for Ifosfamide

Ifosfamide (Ifex®) is a prescription chemotherapy medication that belongs to a group of medicines known as alkylating agents. It is approved for use in combination with other chemotherapy medicines to treat testicular cancer (cancer of the testicles).

What Is Testicular Cancer?

Testicular cancer occurs when cancer cells begin to form in one or both testicles, although normally only one testicle is affected. The testicles are the male reproductive organs located beneath the penis. They sit inside the scrotum.
Testicular cancer is generally rare, accounting for only about 1 percent of all cancers in men in the United States. However, it is the most common form of cancer in men between the ages of 15 and 34.
Most testicular cancer begins from germ cells, the cells of the testicles that make sperm. Ifosfamide is approved specifically for the treatment of germ cell testicular cancer.
Testicular cancer usually responds well to treatment, with more than 95 percent of cases being cured. In general, treatments will vary, depending in part on the type of cancer and how much the disease has progressed. Treatment may include:
Ifosfamide is considered a third-line chemotherapy treatment. This means it is used after at least two other treatments have been tried unsuccessfully.
Because ifosfamide is associated with a potentially serious irritation of the bladder known as hemorrhagic cystitis, it is given in combination with a medication called mesna (Mesnex®). Mesna protects the bladder and helps reduce the chance of developing hemorrhagic cystitis.
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Ifosfamide Drug Information

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