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Ifosfamide

Important Information for Your Healthcare Provider

Talk with your healthcare provider prior to receiving this medication if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • An inability to urinate
  • A slow urine flow
  • An infection of any kind, including a urinary tract infection (UTI, such as a bladder infection)
  • Had radiation treatment
  • Lung disease
  • Heart disease
  • An abnormal heart rhythm (arrhythmia)
  • Anemia (low red blood cells)
  • Bone marrow problems
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
 
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Ifosfamide to learn more, including information on who should not use the drug.)
 

How Does Ifosfamide Work?

Ifosfamide is part of a group of medications called alkylating agents. The medication itself is not active against cancer; however, once it enters the body, the liver converts it into active compounds. These active compounds cause strands of DNA to bond to each other and become linked (this is known as "cross-linking"). The linked strands are unable to uncoil and separate, which is necessary for the DNA to replicate. Because DNA replication is essential for cells to grow and multiply, ifosfamide prevents cell growth and multiplication and causes the cells to die.
 
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Ifosfamide Drug Information

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