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Ifosfamide Bladder Toxicity

Some men who have testicular cancer may benefit from ifosfamide (Ifex®); however, this drug is not appropriate for everyone. It is associated with potentially serious complications, so it is important to discuss the safety precautions with your healthcare provider.
Ifosfamide can cause bladder toxicity in some people. This may result in hemorrhagic cystitis, a condition associated with bladder irritation and blood in the urine. In some cases, this condition may be severe enough to require a blood transfusion and may even lead to death.
To help reduce the risk for this problem, ifosfamide is given in combination with a medication known as mesna (Mesnex®). Tell your healthcare provider immediately if you notice blood in your urine or have pain or burning while urinating, more frequent urination, or a loss of bladder control.
(Click Precautions and Warnings With Ifosfamide for more information on potentially serious complications associated with this drug, including bladder toxicity and other problems. It also explains who should not receive this medicine.)
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