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Drug Interactions With Hydromorphone ER

Benzodiazepines
Taking hydromorphone ER with a benzodiazepine might increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious problems may also occur. Talk to your healthcare provider before combining these medications.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining hydromorphone ER with an MAOI can cause serious reactions. Do not use hydromorphone ER and an MAOI within 14 days of each other.
 
Muscle Relaxants
Taking hydromorphone ER with a muscle relaxant might increase the risk of side effects of both medications. Check with your healthcare provider before combining hydromorphone ER with a muscle relaxant.
 
Other Narcotics or Opiates
Use extreme caution when combining hydromorphone ER with other narcotics or opiates, as serious side effects could occur. You should only use these medications together with your healthcare provider's approval and supervision.
 
Sleep Medications
Hydromorphone ER can cause significant drowsiness, and taking it with a sleep medication could lead to dangerous effects. In general, hydromorphone ER should not be used in combination with sleep medications, unless your healthcare provider specifically recommends that you do so.
 

Final Thoughts

It is possible that not all hydromorphone ER drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
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