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Precautions and Warnings With the Histrelin Implant

Specific Histrelin Implant Warnings and Precautions

Some warnings and precautions to be aware of prior to receiving a histrelin implant include the following:
  • Histrelin implants will cause an initial increase in hormone levels. As a result, your symptoms may initially become worse before improving. Contact your healthcare care provider if your symptoms do not improve within four weeks of receiving the implant.
  • Men who have cancer that has spread to the spine or urinary tract are at risk for a potentially serious urinary tract blockage or spinal pressure at the beginning of treatment, when testosterone levels are high. These problems can lead to paralysis, or even death. Therefore, your healthcare provider may monitor you more closely in the first few weeks of treatment.
  • Your healthcare provider may want to do periodic blood tests to make sure the implant is working to treat your condition. In men with prostate cancer, blood tests may include prostate-specific antigen (PSA test) and testosterone levels. Children will have their hormone levels checked (testosterone in boys and estrogen in girls). Children also will need bone age tests every 6 to 12 months.
  • Histrelin implants may decrease bone density, which can increase the risk for osteoporosis and bone fractures. Certain people are at a higher risk for this side effect, including people who:
    • Already have thin bones (osteoporosis or osteopenia)
    • Regularly use alcohol or tobacco
    • Have a family history of osteoporosis
    • Use medications that affect bone health, such as corticosteroids and antiseizure medications.
  • In rare cases, these implants may cause a condition known as pituitary apoplexy (a stroke in the pituitary gland). Seek immediate medical attention if you develop signs of pituitary apoplexy, such as:
  • These implants have been reported to raise blood sugar levels and increase the risk for diabetes. Your healthcare provider will monitor your blood sugar levels during treatment. If you currently have diabetes, your healthcare provider may have you check your blood glucose levels more often while you are using this medicine.
  • Medications similar to histrelin implants have been reported to increase the risk for strokes, heart attacks, and sudden death in men. Your healthcare provider will evaluate your risk for these problems before starting treatment and periodically thereafter. Seek immediate medical attention if you develop any symptoms of a heart attack or stroke while using this medicine (see Heart Attack Symptoms and Signs of a Stroke).
  • In rare cases, the implant can exit the body through the incision site (the area on your arm where the implant was inserted). If you believe the implant is no longer in your arm, contact your healthcare provider. If the implant cannot be felt through your skin, you may need special tests, such as an ultrasound or computed tomography (CT) scan, to locate it.
  • It is unknown if this medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving the drug (see Histrelin Implant and Breastfeeding).
  • This is a pregnancy Category X medication. It should not be used in women who are pregnant or who may become pregnant (see Histrelin Implant and Pregnancy).
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Histrelin Implant Information

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