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Histrelin Implant

Drug Interactions

The histrelin implant may react with a few other medicines (see Drug Interactions With the Histrelin Implant).

What If I Overdose on This Medicine?

An overdose with this medication is unlikely, as each implant contains a specific amount of medication. However, it is important to seek immediate medical attention if you or someone else may have overdosed on this or any other drug.
(Click Histrelin Implant Overdose for more information.)

What If I Forget a Dose?

This medication is only given once a year. If you forget to schedule an appointment to have your implant removed or replaced, or if you miss an appointment, contact your healthcare provider as soon as you remember. The histrelin implant will provide a few additional weeks of medicine past the 12-month point, so there is some flexibility in dosing.

How Does It Work?

Histrelin implants contain a synthetic (manufactured) form of gonadotropin-releasing hormone (GnRH), a naturally occurring hormone in the body. GnRH controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland (a tiny gland located beneath the brain). LH and FSH stimulate the testes to make testosterone and the ovaries to make estrogen.
Histrelin implants work by overstimulating the pituitary gland so it does not make as much LH and FSH. As a result, the testes stop making testosterone and the ovaries stop making estrogen. This temporarily stops puberty in children with central precocious puberty. It also slows down the growth of prostate cancer cells (which need testosterone to grow and multiply) in men with prostate cancer.
The implant is specially formulated to slowly release medicine into the body for 12 months. After 12 months, the implant must be removed and, if treatment is to continue, a new one inserted.
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Histrelin Implant Information

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