Drug Interactions With Hecoria

Before prescribing Hecoria, it is important for your healthcare provider to be aware of all other medications, vitamins, and herbal supplements you are taking. There are a number of drugs that could cause potentially serious interactions when combined with Hecoria. Some of these products include grapefruit juice, cyclosporine, and live vaccinations.

• Certain blood pressure medicines, including angiotensin-converting enzyme inhibitors (ACE inhibitors) and calcium channel blockers
• Colchicine (Colcrys^®)
• Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
• CYP 3A4 inducer medications, such as:

• • Aminoglutethimide (Cytadren^®)
  • Bosentan (Tracleer^®)
  • Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
  • Dexamethasone (Decadron^®, Dexpak^®, Maxidex^®)
  • Efavirenz (Sustiva^®)
  • Efavirenz, emtricitabine, and tenofovir (Atripla^®)
  • Etravirine (Intelence™)
  • Fosphenytoin (Cerebyx^®)
  • Nafcillin
  • Nevirapine (Viramune^®)
  • Oxcarbazepine (Trileptal^®)
  • Pentobarbital (Nembutal^®)
  • Phenobarbital (Luminal^®)
  • Phenytoin (Dilantin^®, Phenytek^®)
  • Primidone (Mysoline^®)
  • Rifabutin (Mycobutin^®)
  • Rifampin (Rifadin^®)
  • Rifapentine (Priftin^®)
  • St. John's wort

• CYP 3A4 inhibitor medications, such as:

• • Amprenavir (Agenerase^®)
  • Atazanavir (Reyataz^®)
  • Clarithromycin (Biaxin^®)
  • Conivaptan (Vaprisol^®)
  • Darunavir (Prezista^®)
  • Delavirdine (Rescriptor^®)
  • Erythromycin
  • Fluconazole (Diflucan^®)
  • Fosamprenavir (Lexiva^®)
  • Imatinib (Gleevec^®)
  • Indinavir (Crixivan^®)
  • Isoniazid
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Miconazole
  • Nefazodone (Serzone^®)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Posaconazole (Noxafil^®)
  • Quinidine
  • Ritonavir (Norvir^®)
  • Saquinavir (Fortovase^®, Invirase^®)
  • Telaprevir (Incivek™)
  • Telithromycin (Ketek^®)
  • Voriconazole (Vfend^®)

• Dabigatran (Pradaxa^®)
• Echinacea
• Grapefruit juice
• Leflunomide (Arava^®)
• "Live" vaccinations, such as:

• • Chickenpox vaccine (varicella vaccine)
  • FluMist^® (the nasal vaccine for influenza; the injected vaccine is not live)
  • MMR vaccine (measles, mumps, rubella vaccine)
  • Polio vaccine
  • Rotavirus vaccine
  • Smallpox vaccine
  • Yellow fever vaccine
  • BCG vaccine (used in some countries for tuberculosis)

• Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of these medications)
• Natalizumab (Tysabri^®)
• P-glycoprotein inducers, such as:

• • Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
  • Dexamethasone (Decadron^®)
  • Doxorubicin (Adriamycin^®, Doxil^®)
  • Nefazodone (Serzone^®)
  • Prazosin (Minipress^®)
  • Rifampin (Rifadin^®)
  • St. John's wort
  • Tipranavir (Aptivus^®)
  • Trazodone (Desyrel^®) and trazodone ER (Oleptro™)
  • Vinblastine

• P-glycoprotein inhibitors, such as:

• • Amiodarone (Cordarone^®, Pacerone^®)
  • Atorvastatin (Lipitor^®) or combination medications that contain atorvastatin (Caduet^®, Liptruzet™)
  • Carvedilol (Coreg^®, Coreg CR^®)
  • Clarithromycin (Biaxin^®)
  • Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
  • Darunavir (Prezista^®)
  • Dipyridamole (Persantine^®, also found in Aggrenox^®)
  • Dronedarone (Multaq^®)
  • Erythromycin
  • Grapefruit juice
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lapatinib (Tykerb^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Mefloquine (Lariam^®)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Nilotinib (Tasigna^®)
  • Progesterone
  • Propranolol (Inderal^®, Inderal LA^®, InnoPran XL^®, also found in Inderide^®)
  • Quinidine
  • Ranolazine (Ranexa^®)
  • Reserpine
  • Ritonavir (Norvir^®, also found in Kaletra^®)
  • Saquinavir (Invirase^®)
  • Sunitinib (Sutent^®)
  • Tacrolimus (Prograf^®, Protopic^®)
  • Tamoxifen (Nolvadex^®)
  • Telaprevir (Incivek™)
  • Verapamil (Calan^®, Calan SR^®, Covera-HS^®, Isoptin SR^®, Verelan^®, Verelan PM^®)

• Pimecrolimus (Elidel^®)
• Potassium-sparing diuretics, such as:

• • Amiloride (Midamor^®) or amiloride-HCTZ (Moduretic^®)
  • Spironolactone (Aldactone^®) or spironolactone-HCTZ (Aldactazide^®)
  • Triamterene (Dyrenium^®) or triamterene/HCTZ (Dyazide^®, Maxzide^®)

• Proton pump inhibitors (PPIs), such as:

• • Dexlansoprazole (Dexilant™)
  • Esomeprazole (Nexium^®)
  • Lansoprazole (Prevacid^®, Prevacid^® 24HR)
  • Omeprazole (Prilosec^®, Prilosec OTC^®)
  • Omeprazole and sodium bicarbonate (Zegerid^®, Zegerid OTC™)
  • Pantoprazole (Protonix^®)
  • Rabeprazole (AcipHex^®)

• Silodosin (Rapaflo^®)
• Sirolimus (Rapamune^®)
• Topotecan (Hycamtin^®).