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Drug Interactions With Gefitinib

More Detail on Drug Interactions With Gefitinib

The following sections explain in detail the potentially negative interactions that can occur when gefitinib is combined with any of the drugs listed above.
 
Amphotericin B
Taking gefitinib with amphotericin B could increase your risk for amphotericin B side effects, such as low blood pressure (hypotension) and breathing problems. Your healthcare provider may choose to monitor you more closely if you take these medicines together. 
 
Aripiprazole
Gefitinib may increase the amount of aripiprazole in your body, which could increase your risk for aripiprazole side effects. If you take these medications together, let your healthcare provider know if you are experiencing any side effects.
 
CYP 2D6 Inhibitor Medications
The liver breaks down gefitinib using enzymes known as CYP 2D6 enzymes, and some medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes. Thus, combining gefitinib with one of these drugs may increase the level of gefitinib in your body, increasing your risk for side effects.
 
CYP 3A4 Inducer Medications
The liver breaks down gefitinib using enzymes known as CYP 3A4 enzymes, and some medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining gefitinib with one of these drugs may decrease the level of gefitinib in your body, potentially making it less effective. Your healthcare provider may recommend a higher gefitinib dose (gefitinib 500 mg a day) if you take it with a CYP 3A4 inducer.  
 
CYP 3A4 Inhibitor Medications
The liver breaks down gefitinib using enzymes known as CYP 3A4 enzymes, and some medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining gefitinib with one of these drugs may increase the level of gefitinib in your body, increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take gefitinib with a CYP 3A4 inhibitor.  
 
Digoxin
Gefitinib may decrease the amount of digoxin absorbed into the body, potentially making digoxin less effective. This interaction is only thought to occur with digoxin tablets. Your healthcare provider may choose to monitor you more closely if you take these medicines together, and adjust your digoxin dose if needed.
 
H2 blockers
H2 blockers may decrease the amount of gefitinib absorbed from the stomach into the body, which could decrease the effectiveness of gefitinib. Talk to your healthcare provider before taking an H2 blocker during gefitinib treatment.
 
Metoprolol
Gefitinib may increase blood levels of metoprolol, increasing the risk for metoprolol side effects. This interaction is more likely to occur at higher gefitinib doses (500 mg a day), and is less of a concern with the usual recommended gefitinib dose of 250 mg a day.
 
Proton Pump Inhibitors (PPIs)
PPIs may decrease the amount of gefitinib absorbed from the stomach into the bloodstream. This could make gefitinib less effective. Talk to your healthcare provider before taking a PPI during gefitinib treatment.
 
Topotecan
Gefitinib may increase blood levels of topotecan, increasing the risk for side effects. Talk to your healthcare provider before taking these medicines together.
 
Vinorelbine
Combining gefitinib with vinorelbine could cause abnormally low white blood cells, which would increase the risk for developing infections. If you take these medicines together, your healthcare provider may need to closely monitor your blood cell counts. 
 
Warfarin
Taking gefitinib with warfarin may increase the risk for dangerous bleeding, such as internal bleeding. Your healthcare provider may need to monitor you more closely by regularly checking your prothrombin time ("protime" or PT) and international normalized ratio (INR), if you take these medicines together.
 
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Gefitinib Drug Information

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