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Folotyn Drug Interactions

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Combining NSAIDs with Folotyn may increase the level of Folotyn in the blood, potentially causing toxicity. Talk to your healthcare provider before taking an NSAID during treatment, even nonprescription NSAIDs.
 
Probenecid
Probenecid can affect the way the kidneys and the body handle Folotyn. This could cause an accumulation of Folotyn in the bloodstream, possibly leading to toxicity. Check with your healthcare provider before using these medications together.
 
Salicylates
Combining salicylates with Folotyn may increase the level of Folotyn in the blood, potentially causing toxicity. Talk to your healthcare provider before taking a salicylate during treatment. However, the use of low-dose salicylates, or "baby" aspirin, to protect against heart attacks and strokes is not likely to be a concern.
 
Sapropterin
Folotyn may decrease blood levels of sapropterin, potentially making the drug less effective. Talk to your healthcare provider about this potential interaction if you take both of these medicines.
 
Sipuleucel-T
Sipuleucel-T may be less effective when combined with Folotyn. Talk to your healthcare provider about this possible interaction before using these drugs together.
 
Sulfamethoxazole/Trimethoprim
Sulfamethoxazole and trimethoprim may decrease the amount of Folotyn removed from the body by the kidneys. This could cause an accumulation of Folotyn in the blood, potentially leading to toxicity. Talk to your healthcare provider before using these medicines together.
 
Warfarin
Chemotherapy medicines, including Folotyn, have been reported to increase and decrease the effects of warfarin. Because of these variable effects, your healthcare provider may choose to monitor you more closely by checking your prothrombin time ("protime" or PT) and international normalized ratio (INR) when you first start or stop using Folotyn.
 
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Folotyn Medication Information

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