When treating peripheral T-cell lymphoma with Folotyn, the individual dosage is calculated based on a person's weight and height. The prescription drug comes as an intravenous (IV) injection given once a week for six weeks, followed by a one-week break. This treatment cycle is repeated as long as the medicine is working and is not causing serious side effects.
An Introduction to Dosing With FolotynThe dose of Folotyn® (pralatrexate) your healthcare provider recommends will vary, based on a number of factors, including:
- Your height and weight
- How well you tolerate the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
What Is the Recommended Folotyn Dosage?Folotyn is dosed based on body surface area, which is calculated using height and weight, and is expressed as milligrams per meters squared (mg per m2). The usual recommended dosage of Folotyn for treating peripheral T-cell lymphoma is 30 mg per m2 given once a week for six weeks, followed by a one-week break. This seven-week cycle will repeat as long as the medicine is working and is not causing serious side effects.
Your healthcare provider will monitor you for potentially serious Folotyn side effects throughout treatment. He or she may adjust your dose or recommend you skip a dose or stop treatment if you experience certain reactions, such as severe mouth sores or low blood cell counts.
You will need to take folic acid and vitamin B12 during Folotyn treatment to help prevent certain potentially serious side effects. The usual folic acid dosage is 1 mg to 1.25 mg (1000 mcg to 1250 mcg) daily, starting 10 days before the first Folotyn dose and continuing for at least 30 days after the last dose. The usual vitamin B12 dose is 1 mg injected into a muscle (an intramuscular, or IM, injection) starting no more than 10 weeks before the first Folotyn dose and then every 8 to 10 weeks throughout treatment.