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Fentora Side Effects

Notify your healthcare provider if you develop serious side effects while taking Fentora, such as seizures, difficulty breathing, or severe constipation. In most cases, however, people tolerate the medication quite well, and any side effects that occur are typically easy to treat. Common side effects include dizziness, nausea, and vomiting. Other, less-common side effects may include fever, heartburn, and dry mouth.

An Introduction to Fentora Side Effects

As with any medicine, Fentora® (fentanyl buccal tablets) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of Fentora's possible side effects. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Fentora

Fentora has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in people who were taking Fentora were carefully documented. In all of the studies, long-acting opioid narcotics were used in addition to Fentora. Therefore, it can be difficult to know whether the side effects observed were due to Fentora or the other opioid medication.
In clinical studies, the most common Fentora side effects included:
  • Nausea -- in up to 29 percent of people
  • Vomiting -- up to 20 percent
  • Dizziness -- up to 19 percent
  • Tiredness (fatigue) -- up to 16 percent
  • Swelling of the legs, ankles, or feet (edema) -- up to 12 percent
  • Constipation -- up to 12 percent
  • Weakness -- up to 11 percent
  • Dehydration -- up to 11 percent
  • Headaches -- up to 10 percent
  • Shortness of breath -- up to 9 percent
  • Drowsiness -- up to 9 percent
  • Diarrhea -- up to 8 percent
  • Decreased appetite -- up to 8 percent
  • Coughing -- up to 7 percent
  • Confusion -- up to 7 percent
  • Weight loss -- up to 7 percent
  • Pneumonia -- up to 6 percent
  • Low blood potassium levels (hypokalemia) -- up to 6 percent
  • Pain, including joint and back pain -- up to 6 percent
  • Insomnia -- up to 6 percent.
Other side effects that occurred in at least 1 percent of people who were taking Fentora in clinical trials included:
  • An increased heart rate
  • Abdominal (stomach) pain
  • Inflammation of the lining of the mouth or tongue
  • Dry mouth
  • Indigestion or heartburn
  • Difficulty swallowing
  • Fever
  • Chills
  • Chest pain
  • Yellowing of the whites of the eyes or skin (jaundice)
  • Infections, including urinary tract infections (UTIs), respiratory tract infections, and skin infections
  • Tooth abscess (an infection at the root of the tooth)
  • Falls
  • Compression fracture of the spine (when the spinal vertebrae are compressed and break)
  • Increases in blood sugar levels
  • Muscle pain
  • Neck and shoulder pain
  • Itching
  • Rash
  • Cold sweats
  • Increased or decreased blood pressure (hypertension or hypotension)
  • Anemia or other blood cell problems
  • Blood clot in the leg.
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