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Side Effects of Fentanyl Sublingual Spray

Common side effects of fentanyl sublingual spray include dizziness, vomiting, and constipation. While these side effects generally require little or no treatment, potentially serious complications are possible while taking this drug. If you develop more serious reactions, such as hostility, confusion, or the urge to use more fentanyl sublingual spray, contact your healthcare provider right away.

An Introduction to Side Effects of Fentanyl Sublingual Spray

Just like any medicine, fentanyl sublingual spray (Subsys®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with this drug. Your healthcare provider can discuss a more complete list with you.)

Serious Fentanyl Sublingual Spray Side Effects

Some side effects of this medication are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • The urge to use more fentanyl sublingual spray than prescribed or for a nonmedical purpose (see Subsys Abuse)
  • Any difficulty breathing, including reduced, shallow, slow, or irregular breathing
  • Cold and clammy skin
  • A slow heart rate (bradycardia)
  • Extreme drowsiness, especially when accompanied by slow breathing
  • Feeling faint, extremely dizzy, or confused
  • Severe constipation
  • Unusual changes in behavior or mood, such as:
  • Hallucinations (seeing or hearing things that are not really there)
  • Pain, irritation, or sores in the mouth
  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
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Fentanyl Sublingual Spray Information

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