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Side Effects of Fentanyl Sublingual Spray

Common Side Effects

Fentanyl sublingual spray has been studied extensively in clinical trials. In these studies, the side effects that occurred in people given the medication were carefully recorded. In all the studies, long-acting opioid narcotics were used in addition to fentanyl sublingual spray. Therefore, it can be difficult to know whether the reactions observed were due to fentanyl sublingual spray or the other opioid medications.
 
In clinical studies, the most common side effects included:
 
  • Nausea -- in up to 13 percent of people
  • Vomiting -- up to 10.3 percent
  • Drowsiness -- up to 9.5 percent
  • Dizziness -- up to 7.2 percent
  • Constipation -- up to 5 percent.
 
Other side effects that occurred in at least 1 percent of people given fentanyl sublingual spray in clinical trials included:
 
  • A rapid heart rate (tachycardia)
  • Diarrhea
  • Mouth sores
  • Dry mouth
  • Irritation under the tongue
  • Fever
  • Swelling or water retention in the hands, feet, or lower legs
  • Fatigue
  • General weakness
  • Decreased appetite
  • Lethargy
  • Sedation
  • Shakiness (tremors)
  • Headache
  • Depression
  • Confusion
  • Hallucinations
  • Insomnia
  • Shortness of breath
  • Itching.
 

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
 
Therefore, make sure to let your healthcare provider know if you develop any side effects while using fentanyl sublingual spray or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
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Fentanyl Sublingual Spray Information

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