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Drug Interactions With Fentanyl Sublingual Spray

CYP 3A4 Inhibitor Medications
The liver breaks down fentanyl sublingual spray using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining fentanyl sublingual spray with one of these CYP 3A4 inhibitors may increase the level of fentanyl sublingual spray in your body, increasing your risk for serious side effects, including drowsiness, confusion, and breathing difficulty. Your healthcare provider may monitor you more closely for side effects if you use fentanyl sublingual spray with a CYP 3A4 inhibitor.
 
Desmopressin
Fentanyl sublingual spray can increase the risk of desmopressin side effects. Do not use fentanyl sublingual spray with desmopressin without first speaking with your healthcare provider.
 
Grapefruit Juice
Grapefruit juice may increase the amount of fentanyl sublingual spray in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using this medication.
 
Medications That Cause Drowsiness
Fentanyl sublingual spray causes significant drowsiness. Taking other medications that cause drowsiness with fentanyl sublingual spray may lead to serious side effects, such as extreme sedation, confusion, and breathing problems. Check with your healthcare provider before using fentanyl sublingual spray with other medications that may cause drowsiness.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining fentanyl sublingual spray with an MAOI may potentially cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use fentanyl sublingual spray if you have taken an MAOI within the past 14 days.
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Fentanyl Sublingual Spray Information

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