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Drug Interactions With Etoposide Phosphate

Cyclosporine
Cyclosporine can significantly increase etoposide phosphate blood levels, which could increase your risk for potentially serious side effects. If you use these medicines together, your healthcare provider may choose to give you a lower etoposide phosphate dosage.
 
CYP 3A4 Inducer Medications
The liver breaks down etoposide phosphate using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining etoposide phosphate with one of these drugs may decrease the level of etoposide phosphate in your bloodstream, potentially making it less effective. Your healthcare provider may recommend you stop taking certain CYP 3A4 inducers before beginning treatment.
 
CYP 3A4 Inhibitor Medications
The liver breaks down etoposide phosphate using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining etoposide phosphate with one of these drugs may increase the level of etoposide phosphate in your bloodstream, increasing your risk for side effects. Your healthcare provider may decrease your etoposide phosphate dose if you use these medications together.
 
Echinacea
Echinacea could make etoposide phosphate less effective. Do not take echinacea during chemotherapy treatment without first speaking with your healthcare provider.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. Because you are more prone to infections during etoposide phosphate treatment, you could become infected with the virus or bacteria used to make the vaccine. Also, live vaccines may be less effective in people using etoposide phosphate. In general, people using this chemotherapy medication should not receive live vaccines. Therefore, you should talk to your healthcare provider before receiving a vaccination.
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Etoposide Phosphate Drug Information

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