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Etoposide Injection

Important Information for Your Healthcare Provider

Talk with your healthcare provider prior to receiving this medication if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • An infection of any kind
  • Anemia (low red blood cells)
  • Been told you have low albumin levels (hypoalbuminemia)
  • Bone marrow problems
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
 
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Etoposide Injection to learn more, including information on who should not use the drug.)
 

How Does It Work?

Etoposide injection belongs to a group of medicines known as podophyllotoxin derivatives. Podophyllotoxins are derived from the Mayapple tree (Podophyllum peltatum). These medications work by interfering with the action of an enzyme known as topoisomerase II.
 
Topoisomerase II helps relax DNA that has been tangled or overwound, which can happen when DNA is unwinding so it can duplicate (DNA duplication is necessary for cells to divide). The enzyme relaxes tightly bound DNA by cutting the DNA strands to relieve the tension and then putting the strands back together.
 
Etoposide binds to topoisomerase II and prevents the enzyme from relaxing DNA. As a result, the DNA strands break. This prevents cells from dividing, which stops the growth of cancer cells.
 
The Dirty, Messy Part of BPH

Etoposide Injection Information

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