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Estramustine Side Effects

Common Side Effects

Estramustine has been studied extensively in clinical trials. In these studies, one group of people received estramustine, while a similar group was given a different medicine. As a result, it was possible to see what side effects occurred, how often they occurred, and how they compared to the other medication.
In these studies, the most common estramustine side effects included:
  • Breast tenderness -- in up to 71 percent of people
  • Mild breast enlargement -- up to 64.5 percent
  • An increase in certain liver enzymes, which could be a sign of liver problems -- up to 33.3 percent
  • Swelling due to water retention (edema) -- up to 20.4 percent
  • Nausea -- up to 16.1 percent
  • Diarrhea -- up to 12.9 percent
  • Shortness of breath -- up to 11.8 percent
  • Minor stomach upset -- up to 11.8 percent
  • Moderate breast enlargement -- up to 10.7 percent.
Other common reactions, occurring in 1.1 percent to 8.6 percent of people, included:
  • Leg cramps
  • Loss of appetite
  • Extreme sleepiness or lack of energy
  • A decrease in white blood cells, which could increase the risk for infections
  • Easy bruising
  • Changes in mood
  • Insomnia
  • Heart failure
  • Heart attack
  • Stroke
  • Blood clot in the vein
  • Blood clot in the lungs
  • Gassiness
  • Itching
  • Dry skin
  • Abdominal (stomach) bleeding
  • Vomiting
  • Burning feelings in the throat
  • Hoarseness
  • Thirst
  • Runny nose
  • Rash
  • Sudden warmth and redness of the face, neck, or chest (flushing)
  • Peeling of the skin on the fingertips
  • Thinning hair
  • Headache
  • Anxiety
  • Chest pain
  • Watery eyes
  • A decrease in platelets, which could increase the risk for bleeding.
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