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Drug Interactions With Estramustine

More Detail on Drug Interactions With Estramustine

The following sections explain in detail the potentially negative interactions that can occur when estramustine is combined with any of the drugs listed above.
 
Amphotericin B
Combining amphotericin B with chemotherapy medicines, including estramustine, may increase the risk for potentially serious amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and breathing problems. Your healthcare provider may choose to monitor you more closely if you take these medicines together.
 
Calcium-Containing Products
Calcium can decrease the amount of estramustine absorbed from the gastrointestinal (GI) tract into the bloodstream, potentially decreasing the medicine's effectiveness. You should take your estramustine doses on an empty stomach, at least one hour before or two hours after any calcium supplements or calcium-rich food or drinks (such as milk).
 
Biologic and Immunologic Medications
Taking estramustine with certain biologic and immunologic medications that suppress the immune system could increase your risk for potentially serious side effects, such as low white blood cell counts, which could increase the risk for infections. You may need to be monitored closely if you take these medicines together. In some cases, your healthcare provider may recommend you not take these drugs together.
 
Echinacea
Echinacea may decrease the effectiveness of estramustine. Do not take these products together without first speaking with your healthcare provider.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. It is generally recommended that people receiving chemotherapy not receive live vaccines. This is because chemotherapy medicines, including estramustine, may increase your risk for infections, and you could become infected with the virus or bacteria used to make a live vaccine. Also, live vaccines may be less effective during chemotherapy treatment. Talk to your healthcare provider before getting a vaccination while you are taking estramustine.
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Estramustine Drug Information

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