Drug Interactions With Erlotinib

H2 blockers, "blood thinners," and other drugs may cause interactions with Erlotinib. When medications react with this cancer medication, it can lead to serious side effects, such as intestinal bleeding. Some interactions can also alter the effectiveness of your medications. To reduce your risk, tell your healthcare provider about any other medications, vitamins, or supplements you are taking before beginning treatment.

An Overview of Erlotinib Interactions

 Erlotinib (Tarceva®) can potentially react with a number of other medications. Some of the drugs that may interact with erlotinib include but are not limited to:
 
  • Antacids (Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
  • Corticosteroids, such as:
    •  
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
  • Medications that "thin" the blood, such as anticoagulant and antiplatelet drugs like:
    •  
 
 
    • Thrombolytics, such as:
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Drug Interactions With Erlotinib Article Continues on Next Page >
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD
 
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