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Drug Interactions With Erlotinib

More Detail on Drug Interactions With Erlotinib

The following sections explain in detail the potentially negative interactions that can occur when erlotinib is combined with any of the drugs listed above.
 
Antacids
Antacids may decrease the amount of erlotinib absorbed from your stomach into your body, potentially making it less effective. If you take antacids during erlotinib treatment, take the antacid at least three hours before or three hours after your erlotinib dosage.
 
Corticosteroids
Combining erlotinib with a corticosteroid may increase the risk for bleeding, including potentially life-threatening bleeding of the digestive tract. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
CYP 3A4 Inducer Medications
The body breaks down erlotinib using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining erlotinib with one of these drugs may decrease the level of erlotinib in your body, potentially making it less effective.
 
It is generally recommended that erlotinib not be combined with strong CYP 3A4 inducers. If such a combination cannot be avoided, the dose of erlotinib may need to be increased.
 
CYP 3A4 Inhibitor Medications
The body breaks down erlotinib using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining erlotinib with one of these drugs may increase the level of erlotinib in your body, potentially increasing your risk for side effects. The dose of erlotinib may need to be decreased if it is taken in combination with a CYP 3A4 inhibitor.
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Erlotinib Medication Information

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