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Emend Dosage

For the prevention of nausea and vomiting due to chemotherapy, the recommended Emend dosage is 125 mg one hour before chemotherapy, then 80 mg once daily for the next two days. Emend dosing guidelines must be followed as prescribed in order for the medication to work properly.

Emend Dosage: An Introduction

The dose of Emend® (aprepitant) that your healthcare provider recommends will vary depending on a number of factors, including:
  • Whether you are having surgery or chemotherapy
  • Other medications you may be taking
  • Other medical conditions you may have.
As is always the case, do not adjust your Emend dose unless your healthcare provider specifically instructs you to do so.

Emend Dosing for Chemotherapy

The recommended Emend dose for the prevention of nausea and vomiting due to chemotherapy is Emend 125 mg by mouth one hour before chemotherapy (day 1), then 80 mg by mouth once daily in the morning for the next two days (on days 2 and 3). If desired, the first dose of Emend before chemotherapy can be given by IV, instead of by mouth. In this case, the recommended dose is 115 mg by IV (instead of 125 mg by mouth).
When used for chemotherapy, Emend should always be used with other nausea and vomiting medications. Preferably, it should be used with a corticosteroid, such as methylprednisolone (Medrol®) or dexamethasone (Decadron®), and a 5-HT3 antagonist, such as:
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Emend Drug Information

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