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Diindolylmethane
Diindolylmethane is a natural breakdown product of cruciferous vegetables (like broccoli and cauliflower) that is formed during digestion in the stomach. It is also available as a dietary supplement. Diindolylmethane supplements are claimed to be beneficial for a variety of conditions, including cancer. Before using the supplement, you should talk to your healthcare provider if you have liver disease, kidney disease, or any allergies.
Diindolylmethane (DIM) is a breakdown product of indole-3-carbinol, a compound found in broccoli, cauliflower, cabbage, brussels sprouts, and other cruciferous vegetables. It is popular as a dietary supplement and is claimed to be useful for a variety of different purposes, most of which are related to estrogen metabolism or cancer.
(Click Diindolylmethane Benefits for more information on what diindolylmethane is used for, including additional uses.)
Contrary to what many people believe, dietary supplements can cause side effects. However, at this point, little is known about the potential side effects of diindolylmethane in humans.
(Click Side Effects of Diindolylmethane to learn more.)
Diindolylmethane is probably safe for many people at reasonable doses (such as the amounts normally found in foods). Some people may be more likely to experience problems due to the supplement. Therefore, you should talk with your healthcare provider before taking diindolylmethane if you have:
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Kidney disease, including kidney failure (renal failure)
- Cancer (or a history of cancer)
- Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see DIM and Pregnancy)
- Breastfeeding (see DIM and Breastfeeding).
Make sure to tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Is Diindolylmethane Safe? for more information, including any available warnings and precautions.)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD