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What Is Degarelix Used For?

How Does It Work?

Degarelix works by binding to and blocking GnRH receptors in the pituitary gland (a tiny gland located beneath the brain). Normally, GnRH controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which increases the production of testosterone in the testes. By blocking GnRH receptors, degarelix reduces the production and secretion of LH and FSH, resulting in decreased testosterone levels.
Testosterone stimulates the growth of prostate cancer cells. By reducing testosterone levels, degarelix slows down the growth of prostate cancer.
Degarelix is a depot injection. After being injected, the medication forms a small mass, or depot, under the skin. Degarelix is slowly released from this mass into the bloodstream over the course of a month.

Is It Safe for Children to Use Degarelix?

Prostate cancer does not occur in children. Therefore, degarelix is not approved for use in children and has not been adequately studied in children. Talk with your child's healthcare provider about the particular benefits and risks of using this medicine in children.

Can Older Adults Use It?

The majority of men in degarelix studies were at least 65 years old. There were no differences in how well the medication worked, or was tolerated, in older versus younger-aged men. Prostate cancer primarily affects older men. Therefore, degarelix will be primarily used in older men.

Are There Off-Label Uses?

On occasion, your healthcare provider may recommend this medicine for something other than treating advanced prostate cancer. This is known as an "off-label" use. Possible off-label uses of degarelix include the treatment of infertility in women.
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