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Degarelix Side Effects

Common Side Effects

Degarelix has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given degarelix were documented and compared to the side effects that occurred in a group of people given a different prostate cancer medication called leuprolide (Eligard®, Lupron®, Lupron Depot®). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the other medication.
Based on these studies, the most common side effects of degarelix included:
  • Skin reactions at the injection site -- in up to 44 percent of people
  • Hot flushes -- up to 26 percent
  • Weight gain -- up to 11 percent
  • Increases in certain liver enzymes -- up to 10 percent
  • Increased blood pressure (hypertension) -- up to 7 percent
  • Fatigue -- up to 6 percent
  • Back pain -- up to 6 percent
  • Joint pain -- up to 5 percent
  • Constipation -- up to 5 percent
  • Urinary tract infections (UTIs) -- up to 5 percent
  • Chills -- up to 5 percent.
The most common injection site reactions included:
  • Pain
  • Redness
  • Swelling
  • Thickening of the skin around the injection area
  • The appearance of a lump, or nodule, where the medicine was injected.
Injection site reactions were more likely to occur after the first injection. The reactions were generally mild to moderate in severity and usually went away within three days.
Other common degarelix side effects, appearing in 1 to 5 percent of people, included:
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