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Clinical Effects

The effects of degarelix were studied in a clinical trial in men with prostate cancer. In this study, some men were given degarelix and some men were given leuprolide (Eligard®, Lupron®, Lupron Depot®), which is also a GnRH agonist. Both medications reduced testosterone levels to less than 50 nanograms (ng) per deciliter (dL) (a level considered clinically effective) in the majority of men over a 12-month period.
However, like other GnRH agonists, leuprolide caused an initial surge in testosterone levels. Only 18 percent of men given leuprolide had low testosterone levels after two weeks of treatment. In comparison, 96 percent of men receiving degarelix had low testosterone levels within three days. This lack of testosterone surge is one of the advantages of degarelix.

When and How to Use This Medicine

Some general considerations to keep in mind during treatment with degarelix include the following:
  • Degarelix is given as an injection just under the skin (subcutaneously) every four weeks (28 days).
  • The injection is given under the skin of the abdomen (stomach). It is usually given by a healthcare provider in a healthcare setting, such as a doctor's office, hospital, or clinic.
  • The exact site of the injection on your abdomen will change with each dose. The injection should not be given in an area that could be rubbed or pressed against, such as near the waistband, belt, or ribs.
  • For this drug to work properly, it must be used as prescribed. Remember to schedule an appointment to receive your dose every four weeks.

Storage Information

Degarelix should be stored at room temperature. The medication is normally stored by your healthcare provider. Keep this and all other medications out of the reach of children and pets.
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