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Drug Interactions With Dasatinib

If echinacea, live vaccines, or certain other drugs are combined with dasatinib, negative interactions may occur. Taking these medications together could decrease the effectiveness of certain medicines or increase your risk for potentially serious side effects. To help minimize your risk for these and other complications, your healthcare provider needs to know about all medications, supplements, and vitamins you are taking before starting treatment with dasatinib.

An Overview of Dasatinib Interactions

Dasatinib (Sprycel®) may react with a number of other medications. Some of the drugs that can lead to interactions with dasatinib include but are not limited to:
 
  • Antacids (Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
 
 
 
 
  • Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such medications)
  • Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
 
 
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Dasatinib Drug Information

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