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Drug Interactions With Dasatinib

More Detail on Drug Interactions With Dasatinib

The following sections explain in detail the potentially negative reactions that can occur when dasatinib is combined with any of the drugs listed above.
 
Antacids
Antacids may decrease the amount of dasatinib absorbed from your stomach into your body, potentially making it less effective. If you need antacids during dasatinib treatment, take the antacid at least two hours before or two hours after your dasatinib dose.
 
CYP 3A4 Inducer Medications
The liver breaks down dasatinib using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining dasatinib with one of these CYP 3A4 inducers may decrease the level of dasatinib in your body, potentially making it less effective.
 
It is generally recommended that dasatinib not be combined with most CYP 3A4 inducers. However, if such a combination cannot be avoided, your healthcare provider will likely give you a higher dasatinib dose.
 
CYP 3A4 Inhibitor Medications
The liver breaks down dasatinib using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining dasatinib with one of these CYP 3A4 inhibitors may increase the level of dasatinib in your body, potentially increasing your risk for side effects.
 
If you take dasatinib, your healthcare provider may need to lower your dasatinib dose, sometimes to as low as 20 mg daily.
 
Cyclosporine
Dasatinib may increase your blood levels of cyclosporine, possibly increasing your risk for cyclosporine side effects. Your healthcare provider may need to monitor your response to cyclosporine more closely if you take it with dasatinib.
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Dasatinib Drug Information

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