CML and Dasatinib

A healthcare provider may prescribe
 dasatinib (Sprycel®) to help treat a certain type of leukemia called chronic myeloid leukemia (CML). This medication is approved for use in adults age 18 and older.
 
CML is a slowly progressing leukemia in which bone marrow stem cells (the early cells that form blood cells) develop into many abnormal granulocytes (a type of white blood cell). Some of these cells never become mature white blood cells (also called blasts). Over time, the granulocytes and blasts crowd out the red blood cells and platelets in the bone marrow.
 
Dasatinib works to treat CML by reducing the activity of a certain type of protein in the body that the cancer cells need to grow.
 
(Click What Is Dasatinib Used For? for more information, including how dasatinib is used for treating other types of leukemia. This article also covers some unapproved uses for this chemotherapy medication.)
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD