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Drug Interactions With Crizotinib

Lurasidone
Crizotinib can increase blood levels of lurasidone, which could increase your risk for side effects. It is generally recommended that people taking crizotinib receive no more than 40 mg a day of lurasidone.
 
QT-Prolonging Medications
Crizotinib can cause a certain change in the heart rhythm known as QT prolongation. Taking crizotinib with other drugs that may cause QT prolongation can increase your risk for this potentially life-threatening problem. Your healthcare provider may need to monitor the electrical activity of your heart if you take crizotinib with another QT-prolonging medication.
 
Medications That Slow the Heart
Crizotinib commonly causes the heart rate to slow down. Sometimes, it becomes dangerously slow. In general, crizotinib should not be combined with other medications that slow the heart rate, if at all possible.
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove crizotinib from the body, and medications known as Pgp inducers increase the activity of Pgp. When crizotinib is taken with one of these drugs, it may be removed from the body too quickly, potentially making it less effective.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove crizotinib from the body, and medications known as Pgp inhibitors decrease the activity of Pgp. When crizotinib is taken with one of these drugs, it may be removed from the body more slowly, potentially increasing crizotinib blood levels and the risk for side effects.
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Crizotinib Drug Information

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